:root {
  color-scheme: light dark;
  --font-body: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  --bg: #f7f8fa;
  --surface: #ffffff;
  --surface-2: #eef2f5;
  --text: #17202a;
  --muted: #607080;
  --border: #d8e0e7;
  --accent: #0b7285;
  --accent-strong: #075965;
  --accent-soft: #d9f3f7;
  --danger: #b42318;
  --focus: #f59f00;
  --shadow: 0 10px 28px rgba(16, 24, 40, 0.1);
}

:root[data-theme="dark"] {
  --bg: #101418;
  --surface: #171d23;
  --surface-2: #202932;
  --text: #edf2f7;
  --muted: #a7b4c0;
  --border: #33414f;
  --accent: #2db7c8;
  --accent-strong: #75d5df;
  --accent-soft: #153940;
  --danger: #ff8787;
  --focus: #ffd43b;
  --shadow: 0 14px 32px rgba(0, 0, 0, 0.35);
}

* {
  box-sizing: border-box;
}

html {
  min-height: 100%;
}

body {
  margin: 0;
  min-height: 100vh;
  background: var(--bg);
  color: var(--text);
  font-family: var(--font-body);
  line-height: 1.5;
}

a {
  color: var(--accent-strong);
}

button,
input,
select,
textarea {
  font: inherit;
}

:focus-visible {
  outline: 3px solid var(--focus);
  outline-offset: 2px;
}

.skip-link {
  position: fixed;
  left: 1rem;
  top: 1rem;
  z-index: 50;
  transform: translateY(-200%);
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 6px;
  padding: 0.5rem 0.75rem;
}

.skip-link:focus {
  transform: translateY(0);
}

.sr-only {
  position: absolute;
  width: 1px;
  height: 1px;
  padding: 0;
  margin: -1px;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  white-space: nowrap;
  border: 0;
}

.app-shell {
  display: grid;
  grid-template-columns: 18rem minmax(0, 1fr);
  grid-template-rows: 4rem minmax(0, 1fr);
  min-height: 100vh;
}

.topbar {
  grid-column: 1 / -1;
  position: sticky;
  top: 0;
  z-index: 20;
  display: flex;
  align-items: center;
  gap: 1rem;
  padding: 0.65rem 1rem;
  background: color-mix(in srgb, var(--surface) 92%, transparent);
  border-bottom: 1px solid var(--border);
  backdrop-filter: blur(14px);
}

.brand {
  display: inline-flex;
  align-items: center;
  gap: 0.6rem;
  min-width: max-content;
  color: var(--text);
  font-weight: 800;
  text-decoration: none;
}

.brand img {
  display: block;
}

.global-search {
  position: relative;
  flex: 1;
  max-width: 48rem;
}

.global-search input {
  width: 100%;
  border: 1px solid var(--border);
  border-radius: 8px;
  background: var(--surface-2);
  color: var(--text);
  padding: 0.62rem 0.78rem;
}

.search-results {
  position: absolute;
  inset-inline: 0;
  top: calc(100% + 0.35rem);
  max-height: min(28rem, 70vh);
  overflow: auto;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 8px;
  box-shadow: var(--shadow);
  padding: 0.35rem;
}

.search-result {
  display: block;
  border-radius: 6px;
  padding: 0.65rem 0.7rem;
  color: var(--text);
  text-decoration: none;
}

.search-result:hover,
.search-result:focus-visible {
  background: var(--accent-soft);
}

.search-result small {
  display: block;
  color: var(--muted);
}

.topbar-actions {
  display: inline-flex;
  align-items: center;
  gap: 0.5rem;
}

.icon-button {
  display: inline-grid;
  place-items: center;
  width: 2.45rem;
  height: 2.45rem;
  border: 1px solid var(--border);
  border-radius: 8px;
  background: var(--surface);
  color: var(--text);
  cursor: pointer;
}

.nav-toggle {
  display: none;
}

.language-select select {
  min-height: 2.45rem;
  border: 1px solid var(--border);
  border-radius: 8px;
  background: var(--surface);
  color: var(--text);
  padding: 0 0.45rem;
}

.sidebar {
  grid-row: 2;
  background: var(--surface);
  border-right: 1px solid var(--border);
  padding: 1rem;
}

.sidebar nav {
  display: grid;
  gap: 0.3rem;
}

.sidebar a {
  display: flex;
  align-items: center;
  gap: 0.65rem;
  min-height: 2.65rem;
  border-radius: 8px;
  color: var(--text);
  padding: 0.55rem 0.65rem;
  text-decoration: none;
}

.sidebar a[aria-current="page"],
.sidebar a:hover {
  background: var(--accent-soft);
  color: var(--accent-strong);
}

.main {
  min-width: 0;
  padding: clamp(1rem, 2.2vw, 2rem);
}

.page {
  max-width: 1180px;
}

.page-header {
  display: grid;
  gap: 0.35rem;
  margin-bottom: 1.4rem;
}

.page-header h1 {
  margin: 0;
  font-size: clamp(1.8rem, 3vw, 2.7rem);
  line-height: 1.08;
}

.page-header p {
  max-width: 70ch;
  margin: 0;
  color: var(--muted);
}

.grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(min(100%, 16rem), 1fr));
  gap: 1rem;
}

.panel,
.stat-card,
.tool-panel {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 8px;
  padding: 1rem;
}

.stat-card strong {
  display: block;
  font-size: 1.75rem;
}

.muted {
  color: var(--muted);
}

.actions {
  display: flex;
  flex-wrap: wrap;
  gap: 0.65rem;
  margin-top: 1rem;
}

.button {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  gap: 0.45rem;
  min-height: 2.45rem;
  border: 1px solid var(--accent);
  border-radius: 8px;
  background: var(--accent);
  color: #ffffff;
  padding: 0.45rem 0.75rem;
  text-decoration: none;
  cursor: pointer;
}

.button.secondary {
  background: var(--surface);
  color: var(--accent-strong);
}

.text-button {
  border: 0;
  background: transparent;
  color: var(--accent-strong);
  cursor: pointer;
  font-weight: 700;
  padding: 0.35rem 0 0;
  text-align: left;
}

.text-link {
  display: inline-block;
  font-weight: 700;
  margin-right: 0.75rem;
  padding-top: 0.35rem;
}

.data-table {
  width: 100%;
  border-collapse: collapse;
}

.data-table th,
.data-table td {
  border-bottom: 1px solid var(--border);
  padding: 0.65rem;
  text-align: left;
  vertical-align: top;
}

.data-table th {
  color: var(--muted);
  font-size: 0.9rem;
}

.data-table th button {
  border: 0;
  background: transparent;
  color: inherit;
  cursor: pointer;
  font-weight: 700;
  padding: 0;
  text-align: left;
}

.table-scroll {
  margin-top: 1rem;
  overflow-x: auto;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 8px;
}

.catalog-table {
  min-width: 840px;
}

.catalog-table td:first-child {
  max-width: 32rem;
}

.catalog-controls {
  display: grid;
  gap: 0.8rem;
}

.catalog-summary,
.pager {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  justify-content: space-between;
  gap: 0.8rem;
}

.pager {
  margin-top: 1rem;
}

.pager .button:disabled {
  cursor: not-allowed;
  opacity: 0.55;
}

.tag {
  display: inline-flex;
  align-items: center;
  min-height: 1.75rem;
  border: 1px solid var(--border);
  border-radius: 999px;
  background: var(--surface-2);
  padding: 0.15rem 0.55rem;
  font-size: 0.88rem;
  white-space: nowrap;
}

.block {
  display: block;
}

.link-stack {
  display: grid;
  gap: 0.25rem;
  min-width: 6rem;
}

.live-panel {
  margin-top: 1rem;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 8px;
  padding: 1rem;
}

.live-panel h2,
.live-panel h3 {
  margin-bottom: 0.35rem;
}

.explorer-controls {
  margin-bottom: 1rem;
}

.explorer-layout {
  display: grid;
  grid-template-columns: minmax(0, 2fr) minmax(18rem, 1fr);
  gap: 1rem;
  margin-bottom: 1rem;
}

.explorer-card h2,
.explorer-card h3 {
  margin-bottom: 0.35rem;
}

.fact-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(min(100%, 12rem), 1fr));
  gap: 0.7rem;
  margin: 1rem 0;
}

.fact-grid div {
  border: 1px solid var(--border);
  border-radius: 8px;
  padding: 0.7rem;
}

.fact-grid dt {
  color: var(--muted);
  font-size: 0.88rem;
}

.fact-grid dd {
  margin: 0.15rem 0 0;
  overflow-wrap: anywhere;
}

.tag-list {
  display: flex;
  flex-wrap: wrap;
  gap: 0.4rem;
}

.related-list {
  display: grid;
  gap: 0.55rem;
}

.related-item {
  display: grid;
  gap: 0.15rem;
  border: 1px solid var(--border);
  border-radius: 8px;
  color: var(--text);
  padding: 0.65rem;
  text-decoration: none;
}

.related-item:hover {
  background: var(--accent-soft);
}

.related-item span {
  color: var(--muted);
  font-size: 0.9rem;
}

.comparison-table {
  min-width: 720px;
}

.lab-results {
  margin-top: 1rem;
  align-items: start;
}

.sparkline {
  display: flex;
  align-items: center;
  gap: 2px;
  height: 54px;
  border: 1px solid var(--border);
  border-radius: 8px;
  background: var(--surface-2);
  padding: 4px;
  overflow: hidden;
}

.sparkline span {
  display: inline-block;
  width: 5px;
  min-width: 5px;
  align-self: end;
  border-radius: 3px 3px 0 0;
  background: var(--accent);
}

.composition-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(4.4rem, 1fr));
  gap: 0.4rem;
}

.composition-grid div {
  display: grid;
  gap: 0.1rem;
  border: 1px solid var(--border);
  border-radius: 8px;
  padding: 0.45rem;
  text-align: center;
}

.composition-grid small {
  color: var(--muted);
}

.stats-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(min(100%, 24rem), 1fr));
  gap: 1rem;
  margin-top: 1rem;
}

.split-workspace {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(min(100%, 24rem), 1fr));
  gap: 1rem;
  margin-bottom: 1rem;
}

.knowledge-layout {
  display: grid;
  grid-template-columns: minmax(16rem, 20rem) minmax(0, 1fr);
  gap: 1rem;
  align-items: start;
}

.knowledge-nav {
  position: sticky;
  top: 5rem;
  display: grid;
  gap: 1rem;
}

.knowledge-nav nav {
  display: grid;
  gap: 0.25rem;
}

.knowledge-nav nav a {
  border-radius: 8px;
  color: var(--text);
  padding: 0.45rem 0.55rem;
  text-decoration: none;
}

.knowledge-nav nav a:hover,
.knowledge-nav nav a[aria-current] {
  background: var(--accent-soft);
  color: var(--accent-strong);
}

.knowledge-content {
  max-width: none;
}

.bar-list {
  display: grid;
  gap: 0.55rem;
}

.bar-row {
  display: grid;
  grid-template-columns: minmax(8rem, 1fr) minmax(8rem, 2fr) 3rem 4rem;
  align-items: center;
  gap: 0.6rem;
}

.bar-row > span {
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}

.bar-row div {
  height: 0.7rem;
  border-radius: 999px;
  background: var(--surface-2);
  overflow: hidden;
}

.bar-row i {
  display: block;
  height: 100%;
  border-radius: inherit;
  background: var(--accent);
}

.bar-row small {
  color: var(--muted);
  text-align: right;
}

.form-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(min(100%, 14rem), 1fr));
  gap: 0.8rem;
}

.field {
  display: grid;
  gap: 0.3rem;
}

.field input,
.field select,
.field textarea {
  width: 100%;
  border: 1px solid var(--border);
  border-radius: 8px;
  background: var(--surface);
  color: var(--text);
  padding: 0.6rem;
}

.field textarea {
  min-height: 10rem;
  resize: vertical;
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
}

.markdown {
  max-width: 78ch;
}

.markdown h2,
.markdown h3 {
  margin-top: 1.5rem;
}

.markdown code {
  background: var(--surface-2);
  border-radius: 5px;
  padding: 0.1rem 0.25rem;
}

@media (max-width: 820px) {
  .app-shell {
    grid-template-columns: 1fr;
  }

  .topbar {
    flex-wrap: wrap;
    min-height: 4rem;
  }

  .nav-toggle {
    display: inline-grid;
  }

  .brand {
    flex: 1;
  }

  .global-search {
    order: 3;
    flex-basis: 100%;
    max-width: none;
  }

  .sidebar {
    position: fixed;
    inset: 4rem auto 0 0;
    z-index: 30;
    width: min(82vw, 18rem);
    transform: translateX(-102%);
    box-shadow: var(--shadow);
    transition: transform 160ms ease;
  }

  .sidebar[data-open="true"] {
    transform: translateX(0);
  }

  .main {
    grid-column: 1;
  }

  .explorer-layout {
    grid-template-columns: 1fr;
  }

  .bar-row {
    grid-template-columns: 1fr;
    gap: 0.25rem;
  }

  .bar-row small,
  .bar-row strong {
    text-align: left;
  }

  .knowledge-layout {
    grid-template-columns: 1fr;
  }

  .knowledge-nav {
    position: static;
  }
}

.app-footer {
  grid-column: 1 / -1;
  border-top: 1px solid var(--border);
  background: var(--surface);
  color: var(--muted);
  padding: 1rem 1.25rem;
  font-size: 0.85rem;
  display: flex;
  flex-direction: column;
  gap: 0.3rem;
  text-align: center;
}

.app-footer p {
  margin: 0;
}

.app-footer .footer-credit {
  color: var(--text);
  font-weight: 600;
}

.app-footer .footer-credit span[aria-hidden] {
  margin: 0 0.4rem;
  color: var(--muted);
}

.app-footer .footer-meta {
  display: flex;
  flex-wrap: wrap;
  gap: 0.5rem 1rem;
  justify-content: center;
  align-items: center;
}

.app-footer a {
  color: var(--accent-strong);
}

.about-grid {
  align-items: start;
  margin-bottom: 1rem;
}

.about-page .tool-panel {
  margin-bottom: 1rem;
}

.about-page h2 {
  margin-top: 0;
  font-size: 1.2rem;
}

.about-dl {
  margin: 0;
  display: grid;
  gap: 0.25rem 0;
}

.about-dl dt {
  font-weight: 700;
  color: var(--accent-strong);
  margin-top: 0.6rem;
}

.about-dl dt:first-child {
  margin-top: 0;
}

.about-dl dd {
  margin: 0;
  color: var(--text);
}

.about-sources {
  margin: 0.4rem 0 0;
  padding-left: 1.1rem;
  display: grid;
  gap: 0.25rem;
}

.lab-loaded {
  margin: -0.6rem 0 1rem;
  padding: 0.5rem 0.75rem;
  border-left: 3px solid var(--accent);
  background: var(--surface-2);
  border-radius: 0 6px 6px 0;
}

.lab-warning {
  margin: 0.5rem 0 0.75rem;
  padding: 0.55rem 0.8rem;
  border-left: 3px solid #d98a00;
  background: color-mix(in srgb, #d98a00 14%, var(--surface));
  border-radius: 0 6px 6px 0;
  font-size: 0.9rem;
}

.disease-list {
  display: grid;
  gap: 1rem;
  margin-top: 1rem;
}

.disease-card h2 {
  margin: 0 0 0.25rem;
  font-size: 1.25rem;
}

.disease-card-header {
  align-items: start;
}

.disease-flow {
  display: grid;
  gap: 0.65rem;
  margin: 1rem 0;
  padding: 0;
  list-style: none;
}

.disease-flow li {
  display: grid;
  grid-template-columns: minmax(7rem, 0.45fr) minmax(0, 1fr);
  gap: 0.8rem;
  align-items: start;
  border: 1px solid var(--border);
  border-radius: 8px;
  background: var(--surface-2);
  padding: 0.7rem;
}

.disease-flow li + li {
  position: relative;
}

.disease-flow li + li::before {
  content: "↓";
  position: absolute;
  top: -0.78rem;
  left: 1.25rem;
  color: var(--muted);
  font-weight: 700;
}

.disease-flow span {
  color: var(--muted);
  font-size: 0.9rem;
}

.disease-flow strong {
  font-weight: 600;
}

.disease-links {
  border-top: 1px solid var(--border);
  padding-top: 0.8rem;
}

.disease-links .link-stack {
  display: flex;
  flex-wrap: wrap;
  gap: 0.35rem 0.8rem;
}

@media (max-width: 620px) {
  .disease-flow li {
    grid-template-columns: 1fr;
    gap: 0.25rem;
  }
}